Latent inter-organ mechanism of idiopathic pulmonary fibrosis unveiled by a generative computational approach.

ABSTRACT: Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive disease characterized by complex lung pathogenesis affecting approximately three million people worldwide. While the molecular and cellular details of the IPF mechanism is emerging, our current understanding is centered around the lung itself. On the other hand, many human diseases are the products of complex multi-organ interactions. Hence, we postulate that a dysfunctional crosstalk of the lung with other organs plays a causative role in the onset, progression and/or complications of IPF. In this study, we employed a generative computational approach to identify such inter-organ mechanism of IPF. This approach found unexpected molecular relatedness of IPF to neoplasm, diabetes, Alzheimer's disease, obesity, atherosclerosis,

SUBMITTER: Kozawa S 

PROVIDER: S-EPMC10713585 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature