An allele-selective inter-chromosomal protein bridge supports monogenic antigen expression in the African trypanosome.
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ABSTRACT:
SUBMITTER: Faria JRC
PROVIDER: S-EPMC10713589 | biostudies-literature | 2023 Dec
REPOSITORIES: biostudies-literature
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An allele-selective inter-chromosomal protein bridge supports monogenic antigen expression in the African trypanosome.
Faria Joana R C JRC Tinti Michele M Marques Catarina A CA Zoltner Martin M Yoshikawa Harunori H Field Mark C MC Horn David D
Nature communications 20231211 1
UPF1-like helicases play roles in telomeric heterochromatin formation and X-chromosome inactivation, and also in monogenic variant surface glycoprotein (VSG) expression via VSG exclusion-factor-2 (VEX2), a UPF1-related protein in the African trypanosome. We show that VEX2 associates with chromatin specifically at the single active VSG expression site on chromosome 6, forming an allele-selective connection, via VEX1, to the trans-splicing locus on chromosome 9, physically bridging two chromosomes ...[more]
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