Dopamine precursor depletion affects performance and confidence judgements when events are timed from an explicit, but not an implicit onset.

ABSTRACT: Dopamine affects processing of temporal information, but most previous work has tested its role in prospective tasks, where participants know in advance when the event to be timed starts. However, we are often exposed to events whose onset we do not know in advance. We can evaluate their duration after they have elapsed, but mechanisms underlying this ability are still elusive. Here we contrasted effects of acute phenylalanine and tyrosine depletion (APTD) on both forms of timing in healthy volunteers, in a within-subject, placebo-controlled design. Participants were presented with a disc moving around a circular path and asked to reproduce the duration of one full revolution and to judge their confidence in performance. The onset of the revolution was either known in advance (explicit ons

SUBMITTER: Jovanovic L 

PROVIDER: S-EPMC10713647 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature