Puckered and JNK signaling in pioneer neurons coordinates the motor activity of the Drosophila embryo.

ABSTRACT: Central nervous system organogenesis is a complex process that obeys precise architectural rules. The impact that nervous system architecture may have on its functionality remains, however, relatively unexplored. To clarify this problem, we analyze the development of the Drosophila embryonic Ventral Nerve Cord (VNC). VNC morphogenesis requires the tight control of Jun kinase (JNK) signaling in a subset of pioneer neurons, exerted in part via a negative feedback loop mediated by the dual specificity phosphatase Puckered. Here we show that the JNK pathway autonomously regulates neuronal electrophysiological properties without affecting synaptic vesicle transport. Manipulating JNK signaling activity in pioneer neurons during early embryogenesis directly influences their function as organizers

SUBMITTER: Karkali K 

PROVIDER: S-EPMC10713690 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature