Mendelian randomization analysis to elucidate the causal relationship between small molecule metabolites and ovarian cancer risk.

ABSTRACT:

Background

Small molecule metabolites are potential biomarkers for ovarian cancer. However, the causal relationship between small molecule metabolites and ovarian cancer remains unclear.

Methods

Single nucleotide polymorphisms (SNPs) correlated with 53 distinct small molecule metabolites were identified as instrumental variables (IVs) from comprehensive genome-wide association studies. Aggregate data encompassing 25,509 cases of ovarian cancer and 40,941 controls of European descent were procured from the Ovarian Cancer Association Consortium. To evaluate causative associations, four Mendelian randomization techniques-including inverse-variance weighted, weighted median, maximum likelihood, and MR-Egger regression-were employed.

Results

In total, 242 SNPs were delinea

SUBMITTER: Chang X 

PROVIDER: S-EPMC10713731 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature