Helicobacter pylori-activated fibroblasts as a silent partner in gastric cancer development.

ABSTRACT: The discovery of Helicobacter pylori (Hp) infection of gastric mucosa leading to active chronic gastritis, gastroduodenal ulcers, and MALT lymphoma laid the groundwork for understanding of the general relationship between chronic infection, inflammation, and cancer. Nevertheless, this sequence of events is still far from full understanding with new players and mediators being constantly identified. Originally, the Hp virulence factors affecting mainly gastric epithelium were proposed to contribute considerably to gastric inflammation, ulceration, and cancer. Furthermore, it has been shown that Hp possesses the ability to penetrate the mucus layer and directly interact with stroma components including fibroblasts and myofibroblasts. These cells, which are the source of biophysical and bioch

SUBMITTER: Krzysiek-Maczka G 

PROVIDER: S-EPMC10713772 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature