Heterogeneity matching and IDH prediction in adult-type diffuse gliomas: a DKI-based habitat analysis.

ABSTRACT:

Objective

To explain adult-type diffuse gliomas heterogeneity through diffusion kurtosis imaging-based habitat characteristics and develop and validate a comprehensive model for predicting isocitrate dehydrogenase (IDH) status.

Materials and methods

In this prospective secondary analysis, 103 participants (mean age, 52 years; range, 21-77; 54 [52%] male) pathologically diagnosed with adult-type diffuse gliomas were enrolled between June 2018 and February 2022. The Otsu method was used to generate habitat maps with mean diffusivity (MD) and mean kurtosis (MK) for a total of 4 subhabitats containing 16 habitat features. Habitat heatmaps were created based on the Pearson correlation coefficient. The Habitat imAging aNd clinicraD INtegrated prEdiction SyStem (HANDINESS) was crea

SUBMITTER: Liu Y 

PROVIDER: S-EPMC10713834 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature