A novel approach to estimate moderated treatment effects and moderated mediated effects with continuous moderators.

ABSTRACT: Moderation analysis is used to study under what conditions or for which subgroups of individuals a treatment effect is stronger or weaker. When a moderator variable is categorical, such as assigned sex, treatment effects can be estimated for each group resulting in a treatment effect for males and a treatment effect for females. If a moderator variable is a continuous variable, a strategy for investigating moderated treatment effects is to estimate conditional effects (i.e., simple slopes) via the pick-a-point approach. When conditional effects are estimated using the pick-a-point approach, the conditional effects are often given the interpretation of "the treatment effect for the subgroup of individuals…." However, the interpretation of these conditional effects as subgroup effects

SUBMITTER: Valente MJ 

PROVIDER: S-EPMC10713862 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature