Optimal timing for intubation in patients on non-invasive ventilation: A retrospective cohort study.

ABSTRACT:

Background and aims

The timing of transition from non-invasive ventilation (NIV) to invasive ventilation in the intensive care unit (ICU) is uncertain due to a lack of clinical evidence. This study aimed to identify the optimal timing of intubation in patients with respiratory failure managed with NIVs.

Methods

A single-center observational study was conducted in Tokyo, Japan. Patients in the ICU managed with NIV between 2013 and 2022 were screened. The primary outcome was 28-day invasive ventilator-free days. Statistical analyses used locally estimated scatter plot smoothing (LOESS) and generalized linear mixed models to estimate the association between the timing of transition and prolonged intubation duration.

Results

During the study period, 139 of 589 adult ICU p

SUBMITTER: Abe T 

PROVIDER: S-EPMC10713869 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature