The predictive, preventive, and personalized medicine of insomnia: gut microbiota and inflammation.

ABSTRACT:

Background

The human gut microbiota (GM) has been recognized as a significant factor in the development of insomnia, primarily through inflammatory pathways, making it a promising target for therapeutic interventions. Considering the principles of primary prediction, targeted prevention, and personalized treatment medicine (PPPM), identifying specific gut microbiota associated with insomnia and exploring the underlying mechanisms comprehensively are crucial steps towards achieving primary prediction, targeted prevention, and personalized treatment of insomnia.

Working hypothesis and methodology

We hypothesized that alterations in the composition of specific GM could induce insomnia through an inflammatory response, which postulates the existence of a GM-inflammation-insomnia

SUBMITTER: Chen HW 

PROVIDER: S-EPMC10713890 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature