Cumulative exposure to remnant cholesterol and the risk of fragility fractures: a longitudinal cohort study.

ABSTRACT:

Objective

To investigate the association between cumulative remnant cholesterol (cumRC) and the risk of new-onset fragility fractures.

Methods

This study included individuals who participated in the 2006, 2008, and 2010 Kailuan health examinations. Baseline characteristics were compared between groups according to cumRC quartiles. The incidence density was calculated, and the log-rank test was used to compare the cumulative incidence. Cox proportional hazards models were used to estimate the hazard ratio (HR) and 95% confidence interval (CI), and restricted cubic spline was used to examine the possibly non-linear relation between cumRC and the risk of fragility fractures. Additional analyses were performed with stratification by age (≥ or <65 years).

Results

A total o

SUBMITTER: Hou X 

PROVIDER: S-EPMC10713996 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature