The relationship between gut microbiota and insomnia: a bi-directional two-sample Mendelian randomization research.

ABSTRACT:

Introduction

Insomnia is the second most common mental health issue, also is a social and financial burden. Insomnia affects the balance between sleep, the immune system, and the central nervous system, which may raise the risk of different systemic disorders. The gut microbiota, referred to as the "second genome," has the ability to control host homeostasis. It has been discovered that disruption of the gut-brain axis is linked to insomnia.

Methods

In this study, we conducted MR analysis between large-scale GWAS data of GMs and insomnia to uncover potential associations.

Results

Ten GM taxa were detected to have causal associations with insomnia. Among them, class Negativicutes, genus Clostridiuminnocuumgroup, genus Dorea, genus Lachnoclostrid

SUBMITTER: Li Y 

PROVIDER: S-EPMC10714008 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature