Multiomic integration reveals neuronal-extracellular vesicle coordination of gliotic responses in degeneration.

ABSTRACT: In the central nervous system (CNS), including in the retina, neuronal-to-glial communication is critical for maintaining tissue homeostasis including signal transmission, transfer of trophic factors, and in the modulation of inflammation. Extracellular vesicle (EV)-mediated transport of molecular messages to regulate these processes has been suggested as a mechanism by which bidirectional communication between neuronal and glial cells can occur. In this work we employed multiomics integration to investigate the role of EV communication pathways from neurons to glial cells within the CNS, using the mouse retina as a readily accessible representative CNS tissue. Further, using a well-established model of degeneration, we aimed to uncover how dysregulation of homeostatic messaging between ne

SUBMITTER: Cioanca AV 

PROVIDER: S-EPMC10714032 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature