Increased lethality of respiratory infection by Streptococcus pneumoniae in the Dp16 mouse model of Down syndrome.

ABSTRACT:

Objectives

We sought to investigate whether the Dp16 mouse model of Down syndrome (DS) is more susceptible to severe and lethal respiratory tract infection by Streptococcus pneumoniae.

Study design

We infected controls and Dp16 mice with Streptococcus pneumoniae and measured survival rates. We compared cytokine production by primary lung cell cultures exposed to Streptococcus pneumoniae. We examined lung protein expression for interferon signaling related pathways. We characterized the histopathology and quantified the extent of bronchus-associated lymphoid tissue. Finally, we examined mouse tissues for the presence of oligomeric tau protein.

Results

We found that the Dp16 mouse model of DS displayed significantly higher susceptibility to lethal r

SUBMITTER: Colvin KL 

PROVIDER: S-EPMC10714064 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature