Loss of Bone Morphogenetic Protein-9 Reduces Survival and Increases MMP Activity After Myocardial Infarction.
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ABSTRACT:
SUBMITTER: Bhave S
PROVIDER: S-EPMC10714179 | biostudies-literature | 2023 Oct
REPOSITORIES: biostudies-literature
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Loss of Bone Morphogenetic Protein-9 Reduces Survival and Increases MMP Activity After Myocardial Infarction.
Bhave Shreyas S Esposito Michele M Swain Lija L Qiao Xiaoying X Martin Gregory G Wadhwa Sakshi S Everett Kay K Kapur Navin K NK
JACC. Basic to translational science 20230816 10
No studies have explored a functional role for bone morphogenetic protein (BMP)-9, a transforming growth factor-β superfamily ligand, in cardiac remodeling after myocardial infarction (MI). Using BMP-9 null mice, we observed that loss of BMP-9 decreases survival and increases cardiac rupture after MI. We further observed that loss of BMP-9 not only increases collagen abundance, but also promotes matrix metalloproteinase-9 activity and collagen degradation after MI. These findings identify BMP-9 ...[more]
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