Increased thromboinflammatory load in hereditary angioedema.

ABSTRACT: C1 inhibitor (C1Inh) is a serine protease inhibitor involved in the kallikrein-kinin system, the complement system, the coagulation system and the fibrinolytic system. In addition to the plasma leakage observed in hereditary angioedema (HAE), C1Inh deficiency may also affect these systems, which are important for thrombosis and inflammation. The aim of this study was to investigate the thromboinflammatory load in C1Inh deficiency. We measured 27 cytokines including interleukins, chemokines, interferons, growth factors and regulators using multiplex technology. Complement activation (C4d, C3bc and sC5b-C9/TCC), haemostatic markers (β-thromboglobulin (β-TG), thrombin-antithrombin complexes (TAT), prothrombin fragment 1 + 2 (F1 + 2), active plasminogen activator inhibitor-1 (PAI-1)) and the n

SUBMITTER: Gramstad OR 

PROVIDER: S-EPMC10714191 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature