Continued Treatment With Tirzepatide for Maintenance of Weight Reduction in Adults With Obesity: The SURMOUNT-4 Randomized Clinical Trial.

ABSTRACT:

Importance

The effect of continued treatment with tirzepatide on maintaining initial weight reduction is unknown.

Objective

To assess the effect of tirzepatide, with diet and physical activity, on the maintenance of weight reduction.

Design, setting, and participants

This phase 3, randomized withdrawal clinical trial conducted at 70 sites in 4 countries with a 36-week, open-label tirzepatide lead-in period followed by a 52-week, double-blind, placebo-controlled period included adults with a body mass index greater than or equal to 30 or greater than or equal to 27 and a weight-related complication, excluding diabetes.

Interventions

Participants (n = 783) enrolled in an open-label lead-in period received once-weekly subcutaneous maximum tolerated dose (10 or 15

SUBMITTER: Aronne LJ 

PROVIDER: S-EPMC10714284 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature