Developing multispecies quorum-sensing modulators based on the Streptococcus mitis competence-stimulating peptide.

ABSTRACT: Bacteria utilize quorum sensing (QS) to coordinate many group behaviors. As such, QS has attracted significant attention as a potential mean to attenuate bacterial infectivity without introducing selective pressure for resistance development. Streptococcus mitis, a human commensal, acts as a genetic diversity reservoir for Streptococcus pneumoniae, a prevalent human pathogen. S. mitis possesses a typical comABCDE competence regulon QS circuitry; however, the competence-stimulating peptide (CSP) responsible for QS activation and the regulatory role of the competence regulon QS circuitry in S. mitis are yet to be explored. We set out to delineate the competence regulon QS circuitry in S. mitis, including confirming the identity of the native CSP signal, evaluating the molecular mechanism tha

SUBMITTER: Milly TA 

PROVIDER: S-EPMC10714334 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature