Assessment of Scanning Mobility Particle Sizer (SMPS) for online monitoring of delivered dose in an in vitro aerosol exposure system.

ABSTRACT: Real-time monitoring of dosimetry is critical to mitigating the constraints of offline measurements. To address this need, the use of the Scanning Mobility Particle Sizer (SMPS) to estimate the dose delivered through the Dosimetric Aerosol in Vitro Inhalation Device (DAVID) was assessed. CuO nanoparticles suspended in ethanol at different concentrations (0.01-10 mg/mL) were aerosolized using a Collison nebulizer and diluted with air at a ratio of either 1:3 (setup 1) or 1:18 (setup 2). From the aerosol volume concentrations measured by the SMPS, density of CuO (6.4 g/cm³), collection time (5-30 min), flow rate (0.5 LPM) and deposition area (0.28 cm²), the mass doses (Dose_SMPS) were observed to increase exponentially over time and ranged from 0.02 ± 0.001 to

SUBMITTER: Nannu Shankar S 

PROVIDER: S-EPMC10714344 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature