Investigating the Role of Metabolism for Antibiotic Combination Therapies in Pseudomonas aeruginosa.

ABSTRACT: Antibacterial resistance poses a severe threat to public health; an anticipated 14-fold increase in multidrug-resistant (MDR) bacterial infections is expected to occur by 2050. Contrary to antibiotics, combination therapies are the standard of care for antiviral and anticancer treatments, as synergistic drug-drug interactions can decrease dosage and resistance development. In this study, we investigated combination treatments of a novel succinate dehydrogenase inhibitor (promysalin) with specific inhibitors of metabolism and efflux alongside a panel of clinically approved antibiotics in synergy studies. Through these investigations, we determined that promysalin can work synergistically with vancomycin and antagonistically with aminoglycosides and a glyoxylate shunt pathway inhibitor at su

SUBMITTER: Golden MM 

PROVIDER: S-EPMC10714402 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature