Genetic insights into the association of statin and newer nonstatin drug target genes with human longevity: a Mendelian randomization analysis.

ABSTRACT:

Background

It remains controversial whether the long-term use of statins or newer nonstatin drugs has a positive effect on human longevity. Therefore, this study aimed to investigate the genetic associations between different lipid-lowering therapeutic gene targets and human longevity.

Methods

Two-sample Mendelian randomization analyses were conducted. The exposures comprised genetic variants that proxy nine drug target genes mimicking lipid-lowering effects (LDLR, HMGCR, PCKS9, NPC1L1, APOB, CETP, LPL, APOC3, and ANGPTL3). Two large-scale genome-wide association study (GWAS) summary datasets of human lifespan, including up to 500,193 European individuals, were used as outcomes. The inverse-variance weighting method was applied as the main approach. Sensitivity tests were co

SUBMITTER: Chen H 

PROVIDER: S-EPMC10714481 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature