Stress-related cellular pathophysiology as a crosstalk risk factor for neurocognitive and psychiatric disorders.

ABSTRACT: In this narrative review, we examine biological processes linking psychological stress and cognition, with a focus on how psychological stress can activate multiple neurobiological mechanisms that drive cognitive decline and behavioral change. First, we describe the general neurobiology of the stress response to define neurocognitive stress reactivity. Second, we review aspects of epigenetic regulation, synaptic transmission, sex hormones, photoperiodic plasticity, and psychoneuroimmunological processes that can contribute to cognitive decline and neuropsychiatric conditions. Third, we explain mechanistic processes linking the stress response and neuropathology. Fourth, we discuss molecular nuances such as an interplay between kinases and proteins, as well as differential role of sex hormo

SUBMITTER: Palamarchuk IS 

PROVIDER: S-EPMC10714507 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature