The effect of metformin on senescence of T lymphocytes.

ABSTRACT:

Background

Immunosenescence occurs as people age, leading to an increased incidence of age-related diseases. The number of senescent T cells also rises with age. T cell senescence and immune response dysfunction can result in a decline in immune function, especially in anti-tumor immune responses. Metformin has been shown to have various beneficial effects on health, such as lowering blood sugar levels, reducing the risk of cancer development, and slowing down the aging process. However, the immunomodulatory effects of metformin on senescent T cells still need to be investigated.

Methods

PBMCs isolation from different age population (n = 88); Flow Cytometry is applied to determine the phenotypic characterization of senescent T lymphocytes; intracellular staining is applied t

SUBMITTER: Yang J 

PROVIDER: S-EPMC10714529 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature