Pre-operative clonal hematopoiesis is related to adverse outcome in lung cancer after adjuvant therapy.

ABSTRACT:

Background

Clonal hematopoiesis (CH) frequently progresses after chemotherapy or radiotherapy. We evaluated the clinical impact of preoperative CH on the survival outcomes of patients with non-small cell lung cancer (NSCLC) who underwent surgical resection followed by adjuvant therapy.

Methods

A total of 415 consecutive patients with NSCLC who underwent surgery followed by adjuvant therapy from 2011 to 2017 were analyzed. CH status was evaluated using targeted deep sequencing of blood samples collected before surgery. To minimize the possible selection bias between the two groups according to CH status, a propensity score matching (PSM) was adopted. Early-stage patients were further analyzed with additional matched cohort of patients who did not receive adjuvant therapy.

SUBMITTER: Yun JK 

PROVIDER: S-EPMC10714617 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature