Inflammatory cytokines as mediators of retinal endothelial barrier dysfunction in non-infectious uveitis.

ABSTRACT: Characterised by intraocular inflammation, non-infectious uveitis includes a large group of autoimmune and autoinflammatory diseases that either involve the eye alone or have both ocular and systemic manifestations. When non-infectious uveitis involves the posterior segment of the eye, specifically the retina, there is substantial risk of vision loss, often linked to breakdown of the inner blood-retinal barrier. This barrier is formed by non-fenestrated retinal vascular endothelial cells, reinforced by supporting cells that include pericytes, Müller cells and astrocytes. Across the published literature, a group of inflammatory cytokines stand out as prominent mediators of intraocular inflammation, with effects on the retinal endothelium that may contribute to breakdown of the inner blood-r

SUBMITTER: Ferreira LB 

PROVIDER: S-EPMC10714664 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature