Modulation of functional networks related to the serotonin neurotransmitter system by citalopram: Evidence from a multimodal neuroimaging study.

ABSTRACT:

Background

Selective serotonin reuptake inhibitors (SSRIs) potentiate serotonergic neurotransmission by blocking the serotonin transporter (5-HTT), but the functional brain response to SSRIs involves neural circuits beyond regions with high 5-HTT expression. Currently, it is unclear whether and how changes in 5-HTT availability after SSRI administration modulate brain function of key serotoninergic circuits, including those characterized by high availability of the serotonin 1A receptor (5-HT1AR).

Aim

We investigated the association between 5-HTT availability and 5-HTT- and 5-HT1AR-enriched functional connectivity (FC) after an acute citalopram challenge.

Methods

We analyzed multimodal data from a dose-response, placebo-controlled, double-blind study, in which 45 heal

SUBMITTER: Boucherie DE 

PROVIDER: S-EPMC10714691 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature