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Immune targets to stop future SARS-CoV-2 variants.

ABSTRACT:

Importance

The emergence of SARS-CoV-2 had a major impact across the world. It is true that the collaboration of scientists from all over the world resulted in a rapid response against COVID-19, mainly with the development of vaccines against the disease. However, many viral genetic variants that threaten vaccines have emerged. Our study reveals highly conserved antigenic regions in the vaccines have emerged. Our study reveals highly conserved antigenic regions in the spike protein in all variants of concern (Alpha, Beta, Gamma, Delta, and Omicron) as well as in the wild-type virus. Such immune targets can be used to fight future SARS-CoV-2 variants.

SUBMITTER: Silva Souza M

PROVIDER: S-EPMC10714790 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature

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Immune targets to stop future SARS-CoV-2 variants.

Silva Souza Milena M Pires Farias Jéssica J Barros Luiz Wilson W Birbrair Alexander A Durães-Carvalho Ricardo R de Souza Ferreira Luís Carlos LC Amorim Jaime Henrique JH

Microbiology spectrum 20231115 6

<h4>Importance</h4>The emergence of SARS-CoV-2 had a major impact across the world. It is true that the collaboration of scientists from all over the world resulted in a rapid response against COVID-19, mainly with the development of vaccines against the disease. However, many viral genetic variants that threaten vaccines have emerged. Our study reveals highly conserved antigenic regions in the vaccines have emerged. Our study reveals highly conserved antigenic regions in the spike protein in al ...[more]

PMID: 37966210

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