Spatiotemporal observations of host-pathogen interactions in mucosa during SARS-CoV-2 infection indicate a protective role of ILC2s.

ABSTRACT:

Importance

Our study revealed the spatial interaction between humanized ACE2 and pseudovirus expressing Spike, emphasizing the role of type 2 innate lymphoid cells during the initial phase of viral infection. These findings provide a foundation for the development of mucosal vaccines and other treatment approaches for both pre- and post-infection management of coronavirus disease 2019.

SUBMITTER: Hu W 

PROVIDER: S-EPMC10714800 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature