The population-level impact of Enterococcus faecalis genetics on intestinal colonization and extraintestinal infection.

ABSTRACT:

Importance

Enterococcus faecalis causes life-threatening invasive hospital- and community-associated infections that are usually associated with multidrug resistance globally. Although E. faecalis infections cause opportunistic infections typically associated with antibiotic use, immunocompromised immune status, and other factors, they also possess an arsenal of virulence factors crucial for their pathogenicity. Despite this, the relative contribution of these virulence factors and other genetic changes to the pathogenicity of E. faecalis strains remain poorly understood. Here, we investigated whether specific genomic changes in the genome of E. faecalis isolates influence its pathogenicity-infection of hospitalized and nonhospitalized individuals and th

SUBMITTER: Chaguza C 

PROVIDER: S-EPMC10714801 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature