Distinct mode of action of a highly stable, engineered phage lysin killing Gram-negative bacteria.
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ABSTRACT: Importance
Engineered lysins are considered as highly promising alternatives for antibiotics. Our previous screening study using VersaTile technology identified 1D10 as a possible lead compound with activity against Acinetobacter baumannii strains under elevated human serum concentrations. In this manuscript, we reveal an unexpected mode of action and exceptional thermoresistance for lysin 1D10. Our findings shed new light on the development of engineered lysins, providing valuable insights for future research in this field.
SUBMITTER: Gerstmans H
PROVIDER: S-EPMC10714810 | biostudies-literature | 2023 Nov
REPOSITORIES: biostudies-literature
Publications
Distinct mode of action of a highly stable, engineered phage lysin killing Gram-negative bacteria.
Gerstmans Hans H Duyvejonck Lisa L Vázquez Roberto R Staes Ines I Borloo Jimmy J Abdelkader Karim K Leroy Jeroen J Cremelie Emma E Gutiérrez Diana D Tamés-Caunedo Héctor H Ruas-Madiedo Patricia P Rodríguez Ana A Aertsen Abram A Lammertyn Jeroen J Lavigne Rob R Briers Yves Y
Microbiology spectrum 20231116 6
<h4>Importance</h4>Engineered lysins are considered as highly promising alternatives for antibiotics. Our previous screening study using VersaTile technology identified 1D10 as a possible lead compound with activity against <i>Acinetobacter baumannii</i> strains under elevated human serum concentrations. In this manuscript, we reveal an unexpected mode of action and exceptional thermoresistance for lysin 1D10. Our findings shed new light on the development of engineered lysins, providing valuabl ...[more]
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