A group B Streptococcus indexed transposon mutant library to accelerate genetic research on an important perinatal pathogen.

ABSTRACT:

Importance

Group B Streptococcus (GBS) is a significant global cause of serious infections, most of which affect pregnant women, newborns, and infants. Studying GBS genetic mutant strains is a valuable approach for learning more about how these infections are caused and is a key step toward developing more effective preventative and treatment strategies. In this resource report, we describe a newly created library of defined GBS genetic mutants, containing over 1,900 genetic variants, each with a unique disruption to its chromosome. An indexed library of this scale is unprecedented in the GBS field; it includes strains with mutations in hundreds of genes whose potential functions in human disease remain unknown. We have made this resource freely available to the broader rese

SUBMITTER: Bhavana VH 

PROVIDER: S-EPMC10714824 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature