Transcriptomic profile of the most successful <i>Mycobacterium tuberculosis</i> strain in Aragon, the MtZ strain, during exponential and stationary growth phases.

ABSTRACT:

Importance

Aragon Community suffered, during the first years of the beginning of this century, a large outbreak caused by the MtZ strain, producing more than 240 cases to date. MtZ strain and the outbreak have been previously studied from an epidemiological and molecular point of view. In this work, we analyzed the transcriptomic profile of the strain for better understanding of its success among our population. We have discovered that MtZ has some upregulated virulence pathways, such as the ESX-1 system, the cholesterol degradation pathway or the peptidoglycan biosynthesis. Interestingly, MtZ has downregulated the uptake of iron. Another special feature of MtZ strain is the interruption of desA3 gene, essential for producing oleic acid. Although the strain takes a long time

SUBMITTER: Comin J 

PROVIDER: S-EPMC10714837 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature