Identification and production of novel potential pathogen-specific biomarkers for diagnosis of histoplasmosis.

ABSTRACT:

Importance

Histoplasmosis is considered one of the most important mycoses due to the increasing number of individuals susceptible to develop severe clinical forms, particularly those with HIV/AIDS or receiving immunosuppressive biological therapies, the high mortality rates reported when antifungal treatment is not initiated in a timely manner, and the limitations of conventional diagnostic methods. In this context, there is a clear need to improve the capacity of diagnostic tools to specifically detect the fungal pathogen, regardless of the patient's clinical condition or the presence of other co-infections. The proposed novel pathogen-specific biomarkers have the potential to be used in immunodiagnostic platforms and antifungal treatment monitoring in histoplasmosis. In addition,

SUBMITTER: Puerta-Arias JD 

PROVIDER: S-EPMC10714873 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature