Effects of Dual-Release Hydrocortisone on Bone Metabolism in Primary and Secondary Adrenal Insufficiency: A 6-Year Study.

ABSTRACT:

Context

Patients with primary (PAI) and secondary adrenal insufficiency (SAI) experience bone metabolism alterations, possibly due to excessive replacement. Dual-release hydrocortisone (DR-HC) has shown promising effects on several parameters, but bone metabolism has seldom been investigated.

Objective

We evaluated the long-term effects of once-daily DR-HC on bone in PAI and SAI.

Methods

Patients on immediate-release glucocorticoid therapy were evaluated before and up to 6 years (range, 4-6) after switching to equivalent doses of DR-HC, yielding data on bone turnover markers, femoral and lumbar spine bone mineral density (BMD), and trabecular bone score (TBS).

Results

Thirty-two patients (19 PAI, 18 female), median age 52 years (39.4-60.7), were included. At ba

SUBMITTER: Hasenmajer V 

PROVIDER: S-EPMC10714896 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature