Dataset Information
High prevalence of lipopolysaccharide mutants and R2-pyocin susceptible variants in Pseudomonas aeruginosa populations sourced from cystic fibrosis lung infections.
Ontology highlight
ABSTRACT: Importance
Cystic fibrosis (CF) patients often experience chronic, debilitating lung infections caused by antibiotic-resistant Pseudomonas aeruginosa, contributing to antimicrobial resistance (AMR). The genetic and phenotypic diversity of P. aeruginosa populations in CF lungs raises questions about their susceptibility to non-traditional antimicrobials, like bacteriocins. In this study, we focused on R-pyocins, a type of bacteriocin with high potency and a narrow killing spectrum. Our findings indicate that a large number of infectious CF variants are susceptible to R2-pyocins, even within diverse bacterial populations, supporting their potential use as therapeutic agents. The absence of a clear correlation between lipopolysaccharide (LPS) phenotypes and R-pyocin susceptibility suggests that LPS packing density may play a significant role in R-pyocin susceptibility among CF variants. Understanding the relationship between LPS phenotypes and R-pyocin susceptibility is crucial for developing effective treatments for these chronic infections.
SUBMITTER: Mei M
PROVIDER: S-EPMC10714928 | biostudies-literature | 2023 Dec
REPOSITORIES: biostudies-literature
Publications
High prevalence of lipopolysaccharide mutants and R2-pyocin susceptible variants in <i>Pseudomonas aeruginosa</i> populations sourced from cystic fibrosis lung infections.
Microbiology spectrum 20231025 6
<h4>Importance</h4>Cystic fibrosis (CF) patients often experience chronic, debilitating lung infections caused by antibiotic-resistant <i>Pseudomonas aeruginosa</i>, contributing to antimicrobial resistance (AMR). The genetic and phenotypic diversity of <i>P. aeruginosa</i> populations in CF lungs raises questions about their susceptibility to non-traditional antimicrobials, like bacteriocins. In this study, we focused on R-pyocins, a type of bacteriocin with high potency and a narrow killing sp ...[more]
