Broad-range capsule-dependent lytic Sugarlandvirus against Klebsiella sp.

ABSTRACT:

Importance

The emergence of multi-drug resistant bacteria is a global health problem. Among them, Klebsiella pneumoniae is considered a high-priority pathogen, making it necessary to develop new therapeutic tools to reduce the bacterial burden in an effective and sustainable manner. Phages, bacterial viruses, are very promising tools. However, phages are highy specific, rendering large-scale therapeutics costly to implement. This is especially certain in Klebsiella, a capsular bacterium in which phages have been shown to be capsular type dependent, infecting one or a few capsular types through specific enzymes called depolymerases. In this study, we have isolated and characterized novel phages with lytic ability against bacteria from a wide variety of capsular types,

SUBMITTER: Concha-Eloko R 

PROVIDER: S-EPMC10714931 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature