Dataset Information
NDM-1- and OXA-23-producing Acinetobacter baumannii in wastewater of a Nigerian hospital.
Ontology highlight
ABSTRACT: Importance
Acinetobacter baumannii is a leading cause of hospital-associated infections globally. A. baumannii reservoirs outside hospital settings are still unknown, and their occurrence in the environment is linked to clinical and anthropogenic activities. Although the risk of transmission of A. baumannii from environmental sources to humans is not fully understood, these sources pose significant risks for the continued dissemination of A. baumannii and their resistance traits. This study provides evidence that diverse and clinically relevant A. baumannii strains, many of which are resistant to carbapenems, are constantly being discharged into the environment through inadequately treated hospital wastewater. We further elucidate potential transmission routes between the environment and clinical infections and demonstrate the high prevalence of carbapenem resistance genes on highly mobile transposons among these strains. Our findings highlight the pressing need to address hospital wastewater as a crucial factor in curtailing the spread of carbapenem-resistant A. baumannii.
SUBMITTER: Odih EE
PROVIDER: S-EPMC10714947 | biostudies-literature | 2023 Dec
REPOSITORIES: biostudies-literature
Publications
NDM-1- and OXA-23-producing <i>Acinetobacter baumannii</i> in wastewater of a Nigerian hospital.
Microbiology spectrum 20231005 6
<h4>Importance</h4><i>Acinetobacter baumannii</i> is a leading cause of hospital-associated infections globally. <i>A. baumannii</i> reservoirs outside hospital settings are still unknown, and their occurrence in the environment is linked to clinical and anthropogenic activities. Although the risk of transmission of <i>A. baumannii</i> from environmental sources to humans is not fully understood, these sources pose significant risks for the continued dissemination of <i>A. baumannii</i> and thei ...[more]
