Relationships among gut microbes, the interleukin family, and hypertension: a mediation Mendelian randomization study.

ABSTRACT:

Purpose

Observational studies have increasingly recognized the influence of gut microbes on blood pressure modulation. Despite these findings, a direct causal link between gut flora and hypertension remains unestablished due to inherent confounders and the challenges of reverse causality in observational research. In this study, we sought to elucidate the causal relationship between specific gut flora and hypertension and its intermediary mediators.

Methods

We employed a two-sample Mendelian randomization (MR) and mediation MR analysis, analyzing 211 species of gut bacteria, with a focus on the interleukin family as potential mediators and hypertension as the primary outcome. The central methodological technique was inverse variance-weighted estimation, supplemented by vario

SUBMITTER: Zhao S 

PROVIDER: S-EPMC10714948 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature