Inhibition of host cell division by T5 protein 008 (Hdi).

ABSTRACT:

Importance

We have identified a novel phage-encoded inhibitor of the major cytoskeletal protein in bacterial division, FtsZ. The inhibition is shown to confer T5 bacteriophage with a growth advantage in dividing hosts. Our studies demonstrate a strategy in bacteriophages to maximize their progeny number by inhibiting escape of one of the daughter cells of an infected bacterium. They further emphasize that FtsZ is a natural target for bacterial growth inhibition.

SUBMITTER: Mahata T 

PROVIDER: S-EPMC10714956 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature