Diverging humoral and cellular immune responses due to Omicron-a national study from the Faroe Islands.

ABSTRACT:

Importance

The immunity following infection and vaccination with the SARS-CoV-2 Omicron variant is poorly understood. We investigated immunity assessed with antibody and T-cell responses under different scenarios in vaccinated and unvaccinated individuals with and without Omicron infection. We found that the humoral response was higher among vaccinated-naïve than unvaccinated convalescent. Unvaccinated with and without infection had comparable low humoral responses, whereas vaccinated with a second or third dose, independent of infection status, had increasingly higher levels. Only a minor fraction of unvaccinated individuals had detectable humoral responses following Omicron infection, while almost all had positive T-cell responses. In conclusion, primary Omicron infection mounts

SUBMITTER: Petersen MS 

PROVIDER: S-EPMC10714973 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature