Cbl-b negatively regulates TLR/MyD88-mediated anti-Toxoplasma gondii immunity.

ABSTRACT:

Importance

This is the first report that a human E3 ubiquitin ligase, Casitas B-lineage lymphoma proto-oncogene B (Cbl-b), functions as a host dependency factor for the intracellular protozoan Toxoplasma gondii and the mechanism for how T. gondii infection inhibits the TLR/MyD88 innate immunity pathway through MyD88 degradation mediated by Cbl-b. This finding is an impactful contribution for understanding the host cell immunity against T. gondii infection.

SUBMITTER: Wei H 

PROVIDER: S-EPMC10714978 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature