A conserved metabolic signature associated with response to fast-acting anti-malarial agents.

ABSTRACT:

Importance

In malaria drug discovery, understanding the mode of action of lead compounds is important as it helps in predicting the potential emergence of drug resistance in the field when these drugs are eventually deployed. In this study, we have employed metabolomics technologies to characterize the potential targets of anti-malarial drug candidates in the developmental pipeline at NITD. We show that NITD fast-acting leads belonging to spiroindolone and imidazothiadiazole class induce a common biochemical theme in drug-exposed malaria parasites which is similar to another fast-acting, clinically available drug, DHA. These biochemical features which are absent in a slower acting NITD lead (GNF17) point to hemoglobin digestion and inhibition of the pyrimidine pathway as potential

SUBMITTER: Simwela NV 

PROVIDER: S-EPMC10714989 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature