A monoclonal antibody targeting spore wall protein 1 inhibits the proliferation of <i>Nosema bombycis</i> in <i>Bombyx mori</i>.

ABSTRACT:

Importance

There are a few reports on the resistance of microsporidia, including Nosema bombycis. Here, the alkali-soluble germination proteins of N. bombycis were used as immunogens to prepare a monoclonal antibody, and its single-chain variable fragments effectively blocked microsporidia infection. Our study has provided novel strategies for microsporidiosis control and demonstrated a useful method for the potential treatment of other microsporidia diseases.

SUBMITTER: Yu B 

PROVIDER: S-EPMC10714992 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature