Inhibition of HSP90 distinctively modulates the global phosphoproteome of <i>Leishmania mexicana</i> developmental stages.

ABSTRACT:

Importance

In the unicellular parasites Leishmania spp., the etiological agents of leishmaniasis, a complex infectious disease that affects 98 countries in 5 continents, chemical inhibition of HSP90 protein leads to differentiation from promastigote to amastigote stage. Recent studies indicate potential role for protein phosphorylation in the life cycle control of Leishmania. Also, recent studies suggest a fundamentally important role of RNA-binding proteins (RBPs) in regulating the downstream effects of the HSP90 inhibition in Leishmania. Phosphorylation-dephosphorylation dynamics of RBPs in higher eukaryotes serves as an important on/off switch to regulate RNA processing and decay in response to extracellular signals and cell cycle check points. In the curren

SUBMITTER: Porta EO 

PROVIDER: S-EPMC10715028 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature