A genomic survey of Clostridioides difficile isolates from hospitalized patients in Melbourne, Australia.

ABSTRACT:

Importance

There has been a decrease in healthcare-associated Clostridioides difficile infection in Australia, but an increase in the genetic diversity of infecting strains, and an increase in community-associated cases. Here, we studied the genetic relatedness of C. difficile isolated from patients at a major hospital in Melbourne, Australia. Diverse ribotypes were detected, including those associated with community and environmental sources. Some types of isolates were more likely to carry antimicrobial resistance determinants, and many of these were associated with mobile genetic elements. These results correlate with those of other recent investigations, supporting the observed increase in genetic diversity and prevalence of community-associated C. difficile

SUBMITTER: Larcombe S 

PROVIDER: S-EPMC10715045 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature