Wolbachia interferes with Zika virus replication by hijacking cholesterol metabolism in mosquito cells.

ABSTRACT: Zika virus is a member of the arbovirus Flaviviridae family transmitted by Aedes mosquitos and it is associated with microcephaly in infants born to infected mothers. Wolbachia is an intracellular gram-negative alpha-proteobacteria that infects many species of arthropods, including mosquitos. The presence of Wolbachia in mosquitos has been shown to control the vector population and suppress arbovirus transmission. One mechanism of Wolbachia-mediated interference with virus replication is competition over host resources between Wolbachia and the virus. We hypothesize that cholesterol metabolism is involved in Wolbachia-mediated virus suppression due to its important role in Zika virus replication. In this study, we determined that Wolbachi

SUBMITTER: Edwards B 

PROVIDER: S-EPMC10715073 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature