Essential role of Helicobacter pylori apolipoprotein N-acyltransferase (Lnt) in stomach colonization.

ABSTRACT: Bacterial lipoproteins are post-translationally modified with acyl chains, anchoring these proteins to bacterial membranes. In Gram-negative bacteria, three enzymes complete the modifications. Lgt (which adds two acyl chains) and LspA (which removes the signal peptide) are essential. Lnt (which adds a third acyl chain) is not essential in certain bacteria including Francisella tularensis, Neisseria gonorrhoeae, and Acinetobacter baumannii. Deleting lnt results in mild to severe physiologic changes. We previously showed lnt is not essential for Helicobacter pylori growth in vitro. Here, the physiologic consequences of deleting lnt in H. pylori and the role of Lnt in the host response to H. pylori were examined using in

SUBMITTER: Jung MS 

PROVIDER: S-EPMC10715074 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature