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Susceptibility to caspofungin is regulated by temperature and is dependent on calcineurin in Candida albicans.
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ABSTRACT: Importance
Echinocandins are the newest antifungal drugs and are first-line treatment option for life-threatening systemic infections. Due to lack of consensus regarding what temperature should be used when evaluating susceptibility of yeasts to echinocandins, typically either 30°C, 35°C, or 37°C is used. However, the impact of temperature on antifungal efficacy of echinocandins is unexplored. In the current study, we demonstrated that Candida albicans laboratory strain SC5314 was more susceptible to caspofungin at 37°C than at 30°C. We also found that calcineurin was required for temperature-modulated caspofungin susceptibility. Surprisingly, the altered caspofungin susceptibility was not due to differential expression of some canonical genes such as FKS, CHS, or CHT genes. The molecular mechanism of temperature-modulated caspofungin susceptibility is undetermined and deserves further investigations.
SUBMITTER: Zheng L
PROVIDER: S-EPMC10715083 | biostudies-literature | 2023 Dec
REPOSITORIES: biostudies-literature
Publications
Susceptibility to caspofungin is regulated by temperature and is dependent on calcineurin in <i>Candida albicans</i>.
Microbiology spectrum 20231115 6
<h4>Importance</h4>Echinocandins are the newest antifungal drugs and are first-line treatment option for life-threatening systemic infections. Due to lack of consensus regarding what temperature should be used when evaluating susceptibility of yeasts to echinocandins, typically either 30°C, 35°C, or 37°C is used. However, the impact of temperature on antifungal efficacy of echinocandins is unexplored. In the current study, we demonstrated that <i>Candida albicans</i> laboratory strain SC5314 was ...[more]
