Genetic and phenotypic characterizations of IncX3 plasmids harboring bla _NDM-5 and bla _NDM-16b in Japan.

ABSTRACT:

Importance

IncX3 plasmids harboring bla _NDM-5 play a major role in the spread of carbapenem resistance in Asia, particularly in China, in clinical and environmental settings. In this study, we present that Enterobacterales isolates carrying IncX3 plasmids harboring bla _NDM-5 have been disseminated in Japan, where their identification was previously rare. In addition, bla _NDM-16b, a single-nucleotide variant of bla _NDM-5, was found to be carried by an identical IncX3 plasmid. A comparative sequence analysis revealed that the bla _NDM-16b gene emerged from a single nucleotide substitution on an IncX3 plasmid harboring bla _NDM-5. The bla _NDM-16b gene did not con

SUBMITTER: Zuo H 

PROVIDER: S-EPMC10715108 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature