Protein engineering in the computational age: An open source framework for exploring mutational landscapes in silico.

ABSTRACT: The field of protein engineering has seen tremendous expansion in the last decade, with researchers developing novel proteins with specialised functionalities for a range of uses, from drug discovery to industrial biotechnology. The emergence of computational tools and high-throughput screening technology has substantially sped up the process of protein engineering. However, much of the expertise required to engage in such projects is still concentrated in the hands of a few specialised individuals, including computational biologists and structural biochemists. The international Genetically Engineered Machine (iGEM) competition represents a platform for undergraduate students to innovate in synthetic biology. Yet, due to their complexity, arduous protein engineering projects are hindered b

SUBMITTER: Bamezai S 

PROVIDER: S-EPMC10715127 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature